Growth Hormone releasing peptide GHRP is a synthetic, unnatural peptide with a powerful stimulating effect. GHRP is mainly responsible for promoting the releasing of growth hormone in the body. The activity of ghrelin is lower than that of ghrelin. It is affected by glucose, free fatty acids, glucocorticoids and exogenous somatostatin, which can inhibit GHRH.
How GHRP Peptides Work
GHRP-2 and GHRP-6 are just amino acid strings, each peptide has 6 parts. To reach the brain, they mimic the hunger hormone. GHRP stimulates the pituitary gland by attaching to G protein-coupled receptors. Regardless of the natural cycle, time and other conditions, it will cause the GH production to peak immediately. The effect is short-lived, your GH production peaks within 30 minutes and returns to normal within the next 3 hours. And this is enough to make all the effects work.
What Are Similarities Between GHRP-2 and GHRP-6
- They are both synthetic peptides.
- They both act on the pituitary gland.
- They both stimulate the pituitary gland to release growth hormone.
- In addition, both are suitable for professional bodybuilding purposes.
- The two hormones are more effective in aerobic and high-intensity strength training.
Both GHRP-2 and GHRP-6 cooperate with GRF to release GH. GHRP can desensitize cells to each other, but it can’t desensitize cells to GRF. The effect of GHRP-2 is inhibited by peptide antagonists, but not affected by GRF antagonists. In conclusion, despite the structural differences between the peptides, it was found that GHRP-2 stimulates rat pituitary cells to release GH through the same receptors and mechanisms as GHRP-6.
Comparison of GHRP-2 VS GHRP-6
The mechanism of GHRP-2 and GHRP-6 on the release of GH was studied in experimental animals. Both of these peptides are associated with the classical effects of growth hormone receptor secretagogue receptor activation, and can significantly increase growth hormone and IGF-1 in experimental animals. It is found that GHRP-2 stimulates rat pituitary cells to release GH through the same receptor, which is slightly different from GHRP-6. ghrp-2 increases the intracellular adenosine 3,5-monophosphate CAMP concentration like growth release factor (GRF), while GHRP-6 causes a decrease in CAMP level.
GHRP-2 peptide doesn’t cause intense hunger like GHRP-6. However, it can stimulate the secretion of more growth hormone. Using GHRP-2 alone can allow users to gain more effective muscle growth under the premise of controlling body fat. If the budget is sufficient, using GHRP-2 and GHRP-6 in combination have the dual effect of fighting aging, increasing lean body mass and controlling body fat.
GHRP-2 is more effective than GHRP-6. The main difference between GHRP 2 and GHRP 6 is the amount of growth hormone released. GHRP 2 releases more growth hormone than GHRP 6. In addition, the peak of GHRP-2 appears within 15 to 60 minutes after administration. Therefore, compared with GHRP 6, its half-life is shorter. Importantly, GHRP 6 increases the absorption of nitrogen in the body and promotes protein production. These proteins can later be used to increase muscle mass and burn excess fat in the body.
When using GHRP-6, the body’s digestion and absorption rate of nutrients will also be significantly improved. GHRP-2 can create a larger growth hormone release amplitude, which can significantly increase the serum growth hormone level for users.
GHRP-2 has better control over the release of prolactin and cortisol.
Clinically, GHRP-6 has the effect of improving joint discomfort. After use, joint lubrication can be obviously improved and pressure reduced. And GHRP-2 can improve blood calcium level, which is of great help to balance endocrine and improve muscle working ability.
GHRP-6 is more suitable for trainers who need to effectively increase lean body mass, while GHRP-2 is relatively suitable for use during the fat loss period or before the competition. Of course, if you want to get a double effect, the best way is to use GHRP-2 and GHRP-6 together.