• Product Name: L-Valine
  • Appearance: White Crystal Powder
  • Application: Pharmaceutical & Feed Additives
  • CAS NO.: 72-18-4
  • MF: C5H11NO2

What Is L-valine

L-valine is the left-handed enantiomer of valine. Valine is one of the 20 kinds of amino acids used by the human body to synthesize proteins, and is chemically called protein amino acid. It is one of the eight essential amino acids and sugar-forming amino acids for the human body. As one of the three protein amino acids with branched chains, valine can form the group of BCCA together with the other two protein amino acids(isoleucine and leucine). L-valine is white crystal or crystalline powder in appearance. L-valine powder is soluble in water, almost insoluble in ethanol. It can promote normal body growth, repair tissue, regulate blood sugar, and provide needed energy.

What Is L-valine Used For

It can be used as food additives, feed additives, fertilizer additives. Commonly used in various food, beverage, health products, medicine, agriculture, biochemical research and many other industrial fields.

  1. The physiological effect of L-valine it twice that of the D-valine. The lack of valine may cause neurological disorders, stop development, weight loss, anemia, etc.
  2. As a nutritional supplement, it can be used together with other essential amino acids to prepare amino acid infusions and comprehensive amino acid preparations.
  1. L-valine supplement is a glycogen amino acid that can support mental vitality, muscle coordination and emotional calm.
  2. It has functions as a nutraceutical, micronutrient, human metabolite. Algal metabolite, saccharomyces cerevisiae metabolite, E. coli metabolite, and mouse metabolite.
  3. It can promote normal body growth, repair tissue, regulate blood sugar, and provide needed energy.
  4. The effects of valine also include stimulating the central nervous system, which is necessary for proper mental function.
  5. Valine can provide the muscles with extra energy to produce glucose to prevent muscle weakness during strenuous exercise.
  6. It can also help to remove excess nitrogen(a potential toxin) from the liver and deliver the nitrogen the body needs to all parts of the body.
  7. Valine amino acid can also help treat liver and gallbladder disease, as well as damage to these organs from alcohol and drug abuse.
  1. Addition of feed grade valine to lactating sow diet can increase milk production. Its mechanism of action is that valine can affect the production of alanine and its release from muscle. Adding valine to sow diet can increase alanine in plasma to meet the demand of mammary gland tissue for glucose raw materials, thereby improve milk production.
  2. Improve animal body function. Valine can promote the transformation of animal bone T cells into mature T cells. Valine deficiency can significantly hinder the growth of thymus and peripheral lymphoid tissue, and inhibit the growth of acid and neutrophils. Chicks deficient in valine have reduced antibody responses to Newcastle disease virus.
  3. Affect animal endocrine level. Studies have shown that adding valine to the diet of lactating snows and rats can increase the concentration of prolactin and production hormones in plasma.

How Does Valine supplement Work in Bodybuilding

  1. Muscle maintenance. Valine is known for its ability to build muscle. It boosts protein production, which is essential for building muscle. Valine supplement can prevent the breakdown of muscle tissue. Taking valine or BCAA supplements may slow or even reverse muscle wasting.
  2. Faster workout recovery. Taking vailne supplements can help reduce post-workout soreness and aid in muscle recovery. Valine, which reduces the breakdown of protein during exercise, may partially prevent this muscle damage, reducing the severity and duration of soreness a person feels after a workout.
  3. Improve endurance. During exercise, your muscles deplete their stores of valine, which causes the amount of valine in your blood to decrease. Adding valine before a workout can ensure your muscle reserves are not depleted, which can improve your exercise endurance.

More About L-valine

When valine is insufficient, the function of the central nervous system of the brain will be disturbed, ataxia and tremor of limbs will appear. By dissecting and slicing the brain tissue, it was found that there was degeneration of red nuclear cells. Patients with advanced liver cirrhosis were prone to hyperinsulinemia due to liver function damage, resulting in a decrease in branched-chain amino acids in the blood. The ratio of branched-chain amino acids to aromatic amino acids was changed from normal. So branched-chain amino acid injections such as valine are commonly used to treat liver failure and the damage caused by alcoholism and drug abuse to these organs. In addition, it can also be used as a therapeutic agent to speed up wound healing.

There are mainly synthetic and fermentation methods.

Synthetic method

  1. Amino isobutanol is produced from isobutyraldehyde and ammonia, then amino isobutyronitrile is synthesized with hydrogen cyanide, and then hydrolyzed.
  2. Hydroxyisobutyronitrile is synthesized from isobutyraldehyde and hydrogen cyanide, then reacted with ammonia to form aminoisobutyronitrile and then hydrolyzed.
  3. Aminoisobutyronitrile is directly synthesized from isobutyraldehyde, sodium cyanide and ammonium chloride, and then hydrolyzed.
  4. Aminoisobutyronitrile is directly synthesized from isobutyraldehyde, sodium cyanide and ammonium chloride, and then hydrolyzed.

The synthetic method is a racemate, which must be separated by racemization. There are many methods for optical resolution, such as enzymatic hydrolysis of acyl-DL-amino acid, and separation by using the solubility difference between free amino acid and acylated form. Chemical synthesis is characterized by high production costs, complex reactions, many steps and many by-products.

Fermentation method

The valine produced by fermentation method is all L-valine powder, and no optical resolution is required. The strains of fermentation method are Micrococcus glutamicum, Brevibacterium ammoniagenes, Escherichia coli and Aerobacter aerogenes. Use glucose, urea, inorganic salts and other medium. Microbial fermentation production has the advantages of low raw material cost, mild reaction conditions and large-scale production. It is a very economical production method.

L-valine is an essential amino acid, which means it can’t be biosynthesized in the body. Therefore, it must be obtained through dietary sources, mainly meat. Dairy products are also high in L-valine, especially cheese. Plant sources of L-valine include grains, mushrooms, peanuts and soybeans. In addition, D-valine is also present in some actinomycins. Although most people can get adequate amounts from their diet, cases of valine deficiency are not uncommon.

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